OBJECTIVE To develop a method for separating and purifying the two main metabolites of tolbutamide, carboxytolbutamide (CTOL) and hydroxytolbutamide (OTOL), from human urine, then identify the production and determine its purity.

• 目的研究从生物体液(尿液)中分离纯化甲苯磺丁脲的两个主要代谢物羟基甲苯磺丁脲(OTOL)和羧基甲苯磺丁脲(CTOL)的方法,并对所得的产物进行鉴定和含量测定。