Now many stata showed that endothelin had powerful effect on renal of physiology or pathology,which took part in the occurrence and development of renal interstitial fibrosis.

• 有研究表明,内皮素作为细胞因子之一参与了肾间质纤维化的发生和发展,而内皮素受体拮抗剂通过拮抗内皮素的作用,而发挥肾保护作用。