No single experimental animal can provide the answer, nor do conventional dose - increment safety studies adequately address the immunological aspects of adjuvant safety (including tolerance effects, hypersensitivity and generation of autoimmunity).

• 单独一只实验动物不能提供答案,传统的剂量递增安全性研究也不足以阐释关于佐剂安全性的免疫学问题(如耐受作用、超敏性和自身免疫的产生等)。