New insights into these mechanisms are now arising from femur, calcaneus, humerus model of cancer pain in murine and tibia model in rats.

• 初步研究表明,癌症痛有其独特的神经化学机制,骨质破坏、外周敏化、中枢敏化及神经侵蚀都参与了癌症痛的产生。