Mutation at nt1858(T?C)counts for 21.7%,of which mutation at nt 1856(C?T) was seen in samples 417,426 and 430.The other mutation such as A?G at nt 1752,C?G at nt1799,A?T at nt1846,TTC?CGT at nt 1802-1804 count for 17.4%,47.8%,26.1% and 17.4% respectively.

• 其它的突变有nt1799点突变 (C?G) ,占 47 8%25 ( 11/ 2 3 ) ,为无义突变 ; 有 6例在nt1846发生点突变A?T ,4例nt180 2 - 180 4发生突变 (TTC?CGT) ;