Methods:To research the effects of prenatal cocaine exposure on spatial resolution in the water maze test and observe the development of frontal cortex and hippocampus by toluidine blue staining.

• 方法:运用水迷宫方法观察可卡因对子鼠空间辨别能力的影响;采用甲苯胺蓝染色技术观察额叶皮质及海马的发育情况。结果:可卡因可引起子代寻找平台的潜伏期延长、空间辨别能力下降;