Methods:The effects of different formulation and technics factors on the particle size,drug loading,and drug encapsulation efficiency were evaluated by single factor design and orthogonal design.

• 方法:采用单因素法和正交设计法考察不同影响因素对乳化溶剂挥发法所制得的纳米粒粒径、包封率和载药量的影响。