Methods:Plastic was placed in uterus of rat;Cotton was placed under skin of footpath of rat;The bleeding and clotting times were deter-mined.

• 方法：采用对大鼠子宫内放置塑料管致肿胀；蹊部皮下放置棉球致肉芽肿；对小鼠断尾测定出血凝血时间。