Methods:Microsatellite analysis was performed on 18 HNPCC patients who met Amsterdam criteria and 16 suspected HNPCC patients. Six microsatellite loci including BAT26,D2S123,BAX,IGFIIR,hMSH3 and hMSH6 were used.

• 方法:选择符合Am sterdam标准的HNPCC组大肠癌标本18例,和不符合Am sterdam标准、但高度怀疑为HNPCC的可疑HNPCC组大肠癌标本16例,检测BAT26、D2S123、BAX、IGFIIR、hMSH3和hMSH6 6个微卫星位点的微卫星不稳在两组中的发生率,比较两组微卫星不稳频率的差异。