Methods: Wistar rats were given the AHFS,CCO,MD which had been devided into low, interior,and high dosage once a day for 3 months.

• 期间观察各组大鼠体重增长情况,尿中蛋白、尿糖及尿潜血变化情况,肾功能指标及组织形态学改变情况。