Methods: The activated folic acid (N-hydroxysuccinimide ester of folic acid) was conjuated to the surface of bovine serum albumin nanoparticles (BSANP) via the amino groups.

• 方法利用叶酸活性酯在?A性条件下与白蛋白纳米粒表面上的氨基反应，制得叶酸偶联的白蛋白纳米粒。