Methods: In a clinical randomized controlled cross-over trial, 24 patients (All treated with regimens containing cisplatin or adriamycin or theprubicin) were randomized into two groups.

• 方法：24例均接受含顺铂或阿霉素或吡喃阿霉素的联合化疗者随机分为两组，采用双盲法随机双交叉设计，于每组化疗两个周期中交叉用药。