Methods: HBV DNA P genes were amplified by PCR and HBV YMDD mutations were identified by direct sequence compared with Genebank standard sequence. HBV P gene sequence analysis was conducted in 107 chronic hepatitis B (CHB) patients.

• 方法:应用聚合酶链反应(PCR)扩增HBV DNAP基因区,通过直接测序方法与Genebank标准序列对比,对107例慢性乙肝(CHB)患者血清进行P区测序。