Methods The experimented animal model of adjuvant arthritis rats were established by intracutaneous injection of complete Freund s adjuvant at andkle joint site.

• 方法大鼠踝关节皮内注射佐剂造成佐剂性关节炎大鼠模型,分原发性病变预防给药和继发性病变预防、治疗给药3种方案。