Methods SD rats with brain-bearing C6 glioma were established. The subjects included tumor,BAT,BDT and NBT.

• 方法运用中晚期SD大鼠C6脑胶质瘤动物模型,以肿瘤、邻近肿瘤脑组织(BAT)、远隔肿瘤脑组织(BDT)和正常脑组织(NBT)为研究热点区,通过免疫组化分析内源性血清清蛋白血管外渗,判定BBB破坏程度;