Methods In order to get Sotalol,benzenamine was acetylated by methylsulfonylchloride and bromoacetylbro mide b y turns,then substituted with isopropylamine by S N1 reaction and reduced in th e end.

• 方法以苯胺为原料,经甲烷磺酰氯的酰化反应,溴乙酰溴的傅-克酰化反应和异丙胺的分子间亲核取代反应及还原四步合成盐酸索他洛尔。