Methods 724 patients with malignant tumors under the treatment of fluorouracil based chemotherapy were randomized into four groups: A, B, C and D. Patients in group A were treated with allopurinol 0.1gram 3 times a day.

• 方法将724例接受氟脲嘧啶类为主抗癌药物治疗的患者随机分为A、B、C、D组；A组口服别嘌呤醇片0.；1g；3次/d;