Method Plasma concentrations of 9-NC lactone form (lactone 9-NC) and the total of lactone and carboxylate forms (total 9-NC) were determined by the validated HPLC method.

• 方法：采用HPLC法测定大鼠尾静脉注射给药后不同时间点9-NC的内酯型浓度和总浓度并进行药物动力学拟合。