Maternal and child plasma HCY levels were both significantly higher in CHD and VSD groups than that in controls, and maternal and child hyperhomocystinemia are risk factors of CHD and VSD.

• CHD、VSD母子血浆HCY水平均显著高于正常对照组，母子高同型半胱氨酸血症是CHD、VSD发生的危险因素，血浆HCY可作为CHD的一个辅助诊断指标，可协助产前诊断分析，为CHD的早期诊断提供临床借鉴。