Many studies have focused on the DFNA5 gene because it is one of the disease genes of autosomal dominant non-syndromic hearing impairment and it is also associated with melanoma and breast cancer.

• 其中，对该家族的DFNA5基因研究报道相对较多，它是常染色体显性非综合征性耳聋致病基因之一，并可能与黑色素瘤和乳腺癌相关。