Many RGS proteins possess additional non RGS domains and motifs. The non RGS domains are involved to integrate different G protein signaling pathways and as a saffolding protein that links G protein to related signaling proteins.

• 许多RGS蛋白还拥有非RGS结构域,能够结合其它信号蛋白,从而整合和调节G蛋白信号之间以及G蛋白和其它信号系统之间的关系。