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- CpG may be the optimal adjuvant of human esophageal tumor vaccine and the HLA gene locus may affect T cells function. CpG基序是人食管癌疫苗的有效佐剂,HLA对T细胞功能有影响。
- Objective To construct the coexpressing vector of pRSC-mGM-CSF/P1A containing genes of P1A and mGM-CSF for the purpose of developing tumor vaccine. 目的 :构建并鉴定细胞因子mGM CSF和肿瘤特异抗原P1A共表达载体 ,为研究新型的肿瘤疫苗提供新的策略。
- It is current research hotspot to develop tumor vaccine to eliminate or control carcinoma through activating the patients autoimmunity. 研制肿瘤疫苗通过激活患者自身免疫系统以清除或控制肿瘤是当前的研究热点。
- Objective: To investigate the role of T cell in the antitumor immune responses induced by MIF gene-modified tumor vaccine. 目的:研究T细胞在巨噬细胞游走抑制因子(MIF)基因修饰的瘤苗诱导抗肿瘤免疫反应中的作用。
- Purpose To explore the role of New castle disease virus-modified autologous tumor vaccine(NDV-ATV) for treating advanced cervical carcinoma. 探讨新城鸡瘟病毒修饰自体肿瘤细胞疫苗(NDV-ATV)在中、晚期宫颈癌治疗中的作用。
- Objective To discuss the effect of immune function for tumor patient with NDV ATV(new castle disease virus modified autolgous tumor vaccine)treatment after operation. 目的 探讨肿瘤患者术后NDV ATV治疗对免疫功能的影响。
- Objective: To prepare cellular tumor vaccine by fusion of rat Beth - 2 hepatic tumor cellwith activated B lymphocytes and to observe immune related phenotype of the fused cells. 制各大鼠BERH-2肝癌细胞和激活B细胞融合肿瘤疫苗并观察其免疫相关表型,为融合肿瘤疫苗应用人体提供依据。
- As a initiative key tool to treat tumor,the research of tumor vaccine has gained much improved as well as the appearance of molecular biology and genetic engineering technique. 肿瘤疫苗作为肿瘤主动性免疫治疗的重要手段,随着分子生物学的发展和基因工程技术的出现,其研究有了很大的飞跃。
- Conclusion:GM-CSF gene transfered tumor vaccine in RMA tumor model induced better antitumor immune effect and will be a novel approach to ca ncer in the future. 结论:在RMA肿瘤模型中,GM-CSF基因转导的肿瘤细胞瘤苗有较好的抗肿瘤免疫效果,此法有可能成为治疗肿瘤的有效途径。
- The research on tumor vaccine has been a key method of tumor active immunotherapy with the development and application of molecular biological and genetic engineering technology. 随着分子生物学及基因工程技术的出现及应用,肿瘤疫苗的研究已成为主动性免疫治疗的重要手段之一。
- Objective To discuss the effect of newcastle disease virus modified autologous tumor vaccine(NDV ATV) treatment on the immune function of postoperative patients with gastric carcinoma. 目的 探讨新城鸡瘟病毒修饰的自体肿瘤疫苗 (NDV -ATV )治疗胃癌术后患者机体免疫功能的影响。
- Objective To discuss the effect of newcastle diseasevirus-modified autologous tumor vaccine (ATV-NDV) treatment on the immune function of postoperative patients with renal cell carcinoma. 目的 探讨自体瘤苗对肾癌患者免疫功能的影响。 方法 术中切取新鲜肾癌组织,制备成新城鸡瘟病毒(NDV)修饰的自体肿瘤细胞疫苗(ATV-NDV),术后免疫接种。
- Objective: New castle disease virus-modified autologous tumor vaccine (NDV-ATV) is a kind of tumor biotherapy which has been recently used clinically. But its mechanism is still unclear. 目的:新城鸡瘟病毒修饰的自体肿瘤疫苗(New Castle Disease Virus-Modified Autologous Tumor Vaccine,NDV-ATV),是新近用于临床的肿瘤生物治疗方法,但其具体作用机制尚不十分清楚。
- Objective: Our study aimed to investigate the mechanisms of anti-tumor mechanisms and the clinical application value of new castle disease virus modified autologous tumor vaccine (ATV-NDV) in breast cancer's immunotherapy. 目的:研究新城鸡瘟病毒修饰的自体乳腺肿瘤疫苗(ATV-NDV)抗乳腺癌机制,并进行临床应用,以提高乳腺癌患者的机体免疫功能。
- Methods: Fresh tumor tissues were utilized to prepare ATV-NDV which then was used for 19 breast cancer patients's therapy. Cell immune functions of patients in different therapy phases were observed and side effect of the tumor vaccine was analyzed. 方法:用新鲜的肿瘤标本自行制备肿瘤疫苗并用NDV修饰,然后应用于19例乳腺癌患者,分别观察手术前、手术后疫苗治疗前、后三个阶段患者的细胞免疫功能变化,并分析应用肿瘤疫苗后的毒副反应。
- In this paper,we follow the update conception and classification and review the characteristic of CT antigen expression in tumor tissue and normal tissue, and clinical progress as a tumor vaccine. 本文就目前肿瘤-睾丸抗原的定义、分类及其在肿瘤组织及正常组织中表达的特点和作为疫苗的临床研究进展作一综述。
- Conclusion: It is suggested that MIF gene-modified tumor vaccine can induce specific antitumor immune responses mediated by T cells and may be a candidate for gene therapy of tumor. 结论:MIF基因修饰的瘤苗能诱导T细胞介导的抗肿瘤免疫反应,有可能作为肿瘤基因治疗的候选者。
- Methods:Mice were vaccinated with live tumor vaccine of NDV pretreated mice hepatic cancer cell H22. 方法:将经新城疫病毒处理的小鼠肝癌细胞H22为活瘤苗进行免疫接种。
- Dendritic cell-based tumor vaccines can induce tumor models protectitive antitumor immunity,and these inspire us. 树突状细胞瘤苗可诱导荷瘤动物的保护性抗肿瘤免疫应答反应,这一发现使肿瘤治疗领域倍受鼓舞。
- This paper reviews current advances in the preparation and the clinical application of dendritic cell-based tumor vaccines for tumor immunotherapy. 就肿瘤免疫治疗中树突状细胞瘤苗的基础研究与临床应用进展予以综述。