MTHFR C677T genetic polymorphisms were associated with individual susceptibility to esophageal cancer and hypermethylation rate of MGMT gene in the tumor tissues.

• 核苷酸切除修复基因XPC PAT和exon 15多态与食管癌遗传易感性间的联系较弱，叶酸代谢酶基因MTHFR C677T多态可能与食管癌遗传易感性和DNA异常甲基化有关。