METHODS:RP-HPLC were used to determine the concentrations of omeprazole at different times in micro-pump after administrcotion24h by simulating the dose mode in clinical.

• 方法:模拟临床给药方式,分别于给药24h内从微泵出液口取样,采用高效液相色谱法测定奥美拉唑在各时间点的浓度。