METHODS To establish a HPLC method for determing the content of ribavirin.The water-soluble matrix tablet was preparaed by use of HPMC.The optimal formulation was obtained by uniform design.

• 方法:建立高效液相色谱(HPLC)体外释放度测定法,以羟丙基甲基纤维素(HPMC)为主要辅料,制备亲水凝胶型骨架片,采用单因素试验筛选辅料种类,通过均匀设计优化出缓释片的处方。