METHODS Ranolazine was synthesized by using 2, 6-dimethylaniline and guaiacol as the starting matejial fellewed by 4 step reactions.RESULTS The overall yields were 36.8%.

• 方法以2,6-二甲基苯胺、愈创木酚为原料，经酰化、烃化等4步反应制得雷诺嗪。