METHODS Matrine pellets were prepared in a fluid-bed by solution layering and then,coated in a mini fluid-bed by surelease,eudragit or both of them respectively.

• 方法溶液上药法(流化床底喷装置)制备苦参碱微丸,分别选用乙基纤维素、丙烯酸树脂水分散体及两者同时应用作为包衣材料,采用自制微型流化床进行包衣,分别考察其体外释放度。