METHODS Cefsulodin was prepared,taking phenylacetic acid as the starting material,followed by sulfonation,resolution,acylation,amidation and substitution,in 5 steps totally.

• 方法以苯乙酸为原料,经磺化、拆分、酰化、酰胺化和取代五步反应合成头孢磺啶。