METHOD Botox was diluted with normal saline, defined extent of wrinkles, located site and direction of injection, the dose injected varied according to the place of wrinkles.

• 方法将肉毒素用生理盐水稀释,明确皱纹范围,定位注射点和注射方向,注射剂量根据皱纹部位的不同而调整。