MDMA caused the decrease of 5-HT in rat frontal cortex, hippocampus and striatum,but no significant influence on DA; the expression of SERT mRNA was down-regulated significantly.

• 给予MDMA后 ；大鼠额叶皮层、海马和纹状体的 5 -HT下降 (P <0 0 0 1) ；SERTmRNA的表达明显减少 (P <0 0 0 1)。