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- PRN can obviously shorten hypnotic duration of pentobarbital sodium, which suggests that PRN could induce liver microsomal cytochrome P450 in mice. PRN能显著缩短戊巴比妥钠对小鼠的催眠时间 ,提示PRN能诱导小鼠肝微粒体细胞色素P4 5 0活性
- After induced by AFB1 the activity of liver microsomal enzymes in duck has been studied and has been compared with the control groups respectively. 本文对1月龄麻鸭经过黄曲霉毒素诱导后在1月、1年及3年观察其肝微粒体酶(S9)的代谢活性并与各相应对照组进行比较。
- Results and Conclusion : The result s both with and without S9 (rat liver microsomal enzymes) showed that all the samples had no mutagenicity. 结果与结论:经加和不加大鼠肝脏微粒体酶(S9) 两种试验,结果全部受试物均未发现致突变毒性;
- To investigate the effect of Molybdenum on liver microsomal fraction aniline hydroxylase in rats,50 rats were randomly divided into 5 groups. 为研究钼对大鼠肝微粒体中苯胺羟化酶的影响,将50只大鼠随机分为5个组,4个试验组每天分别灌服剂量为8。
- The content of liver microsomal P-450 was decreased, while activities of UDP-GT late fetal (O-GT) and neonatal form (P-GT) and liver cytosol LDH were markedly increased in EAC-bearing mouse. Ehrlich腹水癌带瘤小鼠肝微粒体细胞色素P-450含量低于正常对照组,而UDP-GT的“胚胎型”(O-GT)和“新生儿型”(P-GT)活性及肝细胞浆中LDH活性显著增高。
- The metabolism of diphenytriazol was investigated in five kinds of rat liver microsomal incubate pretreated with phenobarbital (PB), dexamethasone (Dex), p-naphthoflavone (BNF), diphenytriazol and control. 方法:l)用CYPIA、CYPZB的两种特征性底物乙氧基异吩恶吟与7一戊氧基异吩恶吟在经不同天数地非三吟处理的鼠肝微粒体中代谢，用荧光仪在激发波长(ex)565nm，发射波长(em)587nln下直接测定代谢物异吩恶吟的生成量。
- Phenobarbital does not impair normal hepatic function but has been shown to induce liver microsomal enzymes, thus increasing and/or altering the metabolism of barbiturates and other drugs. 苯巴比妥不损害肝脏的功能，但可诱导肝微粒体酶，从而增加或改变巴比妥类和其他药物的代谢。
- liver microsomal activating system 肝微粒体活化系统
- In vitro the experimental results showed that fluoride could significantly increase the content of lipid peroxide (LPO) of rat liver microsome, and the lipid peroxidation was antagonized by adding selenium to liver microsomal system simultaneously. 体外实验结果表明，加氟可使微粒体系统脂质过氧化物（LPO）含量显著增加； 同时加硒可结抗氟致微粒体系统的脂质过氧化作用。
- In this study, we investigated its metabolism by use of rat liver microsome in vitro. 利用大鼠肝微粒体对新农药多噻烷进行体外代谢研究。
- Preliminary data indicate that steviol may be activated to a mutagenic metabloite by human liver microsomes. 初步数据显示,甜菊醇可能经人体的肝脏微粒体活化成引致基因突变的代谢物。
- Based on metabolite analysis, several PAC-1 metabolic pathways in human liver microsomes were proposed. 结论 PAC-1在人肝微粒体系中的代谢途径为脱苄基化和羟基化。
- Effect of ammonium metavanadate on GSH -px of liver microsomal fraction in rats 钒酸铵对肝微粒体谷胱甘肽过氧化物酶活性影响
- The correlation between peak area of a metabolite and original concentration of Nef in rat liver microsomes solution was significant( r =0.993). 温孵液中代谢产物生成的量与底物Nef的浓度具有良好的相关性（r=0.;993）；
- The mean (MEGX+GX)/LDC ratio was 3 2 8. CONCLUSIONThe (MEGX+GX)/LDC ratio can be used to evaluate C YP3A activity of human liver microsomes. 结论 (MEGX +GX) /LDC可用来估算人肝微粒体CYP3A的活性。
- Keywords Bay41-4109;cytochrome P450;liver microsomal;induction effect; 细胞色素P450;肝微粒体;诱导效应;
- The Bradford method was used to measure the concentration of protein in liver microsome, and activities of cytochrome P450 enzymes were determined by the spectrophotometer method. 测定一月龄至八月龄不同性别的猪，肝微粒体蛋白含量、CYP450含量、CYPb5含量、NADPH-细胞色素C还原酶活性、氨基比林-N-脱甲基酶活性、红霉素-N-脱甲基酶活性和苯胺-4-羟化酶活性。
- Antioxidant activities of extractions were determined by chemical methods to produce superoxide free radicals, hydroxide free radicals and lipid peroxide of rat liver microsome. 采用化学方法产生超氧阴离子自由基、羟自由基和小鼠肝匀浆液脂质过氧化体系对提取物进行抗氧化活性检测,研究其清除自由基和抑制脂质过氧化能力的差异。
- The proper conditions for testotesrone metabolism in liver microsome system included substrate concentration, incubation time, pH and incubation temperature. 方法：采用超高速离心法制备大鼠肝脏微粒体，建立体外肝脏微粒体混合酶代谢体系。
- The poor man has a serious disease of the liver. 这个可怜的人患有严重的肝病。
