Keywords rational drug design;3D-QSAR;ADMET;matrix metallloproteinaes inhibitors;pyrrolidine derivatives;chemical synthesis;anti-tumor activity;

• 合理药物设计;3D-QSAR;ADMET;基质金属蛋白酶抑制剂;吡咯烷衍生物;化学合成;抗肿瘤活性;