Keywords human immunodeficiency virus;trichosanthin;ribosome inactivating protein;immunogenicity;site-directed mutagenesis;site-directed PEGylation;

• 人类免疫缺陷病毒;天花粉蛋白;核糖体失活蛋白;免疫原性;定点突变;聚乙二醇定点修饰;