Keywords Heart failure;Myocardium remodeling;FK506 binding protein;Calcium;Ryanodine receptor;Calcineurin;ERK1/2;Rapamycin;

• 心力衰竭;心肌重塑;FK506结合蛋白;钙信号;雷尼丁受体;钙调神经磷酸酶;细胞外信号调节蛋白激酶;雷帕霉素;