Janus kinase/STAT pathway may be involved in modulating HMGB1 mRNA expression in LPS-activated macrophages.

• 结论 LPS可诱导大鼠腹腔巨噬细胞HMGB1mRNA表达 ,其诱生机制与Janus激酶 /信号转导子和转录激活因子 (JAK/STAT )途径密切相关。