Its function was associated with transcription. Conclusions Inhibition expression of DJ-1 protein was involved in HL-60 cells differentiation induced by DADS and might associate with inhibition of JAKs/STATs single pathways via activating PIAS protein.

• 结论DADS可能通过抑制DJ-1蛋白合成,活化PIAS蛋白抑制STATs转录因子的活性,进而抑制JAKs/STATs信号传导通路,诱导HL-60细胞分化。