It was found that FaDu and Detroit 562 cells presented morphological features of apoptosis,increased the rate of marking the nuclear of proliferating cells with BrdU,decreased p21WAF1 gene expression in the presence of RA.

• 维甲酸添加后细胞形态发生细胞凋亡样改变 ；Brd U增殖细胞核掺入率也显著低于对照组( P<0 .；0 1 )；p53蛋白表达无明显变化；p2 1 WAF1蛋白表达增强。