It was found for first time that As2O3 was active to induce MDCC?MSB Ito produce IL-1, IL-2, IL-6 and TNF in external culture. This was the cause and mechanism of apoptosis occurred possibly.

• 首次发现As_2O_3能够诱导体外培养的MD肿瘤细胞系产生细胞因子白细胞介素-1(IL-1)、白细胞介素-2(IL-2)、白细胞介素-6(IL-6)和肿瘤坏死因子(TNT)，此结果可能是引起细胞凋亡的原因和机理之一。