It is the increase of expression and activity of NHE-1 in HL-60/ADM cells that play an important role in that pHi value of HL-60/ADM cells is higher significantly than that of HL-60 cells.

• HL-60/ADM细胞NHE-1的表达及活性增高，是导致HL-60/ADM细胞pHi显著高于HL-60细胞的主要原因。