Intrathecal injection of NOS antisense oligonucleotides (AS-ONs) significantly decreased the scores of morphine-withdrawal symptoms.The effect of nNOS AS-ONs was greater than that of eNOS AS-ONs.

• 结果表明, 鞘内注射NOS反义寡核苷酸能明显减轻吗啡戒断反应, 且脑型NOS (nNOS)反义寡核苷酸的作用强于内皮型NOS (eNOS)反义寡核苷酸。