Induction of apoptosis by Etoposide was associated with up-regulation of mRNAs for the BH3 only proteins Noxa,and to a lesser extent,Bim.

• BH3-only蛋白Noxa的mRNA表达明显上调,Bim少量上调与依托泊苷诱导的细胞凋亡有关系;