In vitro amoxicillin release behavior was investigated using paddle method andamoxicillin concentration determined by UV spectrophotometry. In pH 7.8phosphate buffer, amoxicillin could be sustainedly released from 30% at 2 hrs to 90%at 12 hrs.

• 建立了紫外分光光度法测定粘附微球在 pH7.；8 磷酸盐缓冲液中阿莫西林释放度的方法；阿莫西林粘膜粘附微球 2h 释药 30%25左右；并能缓释至 12h；释药量达 90%25。