In this thesis,a rapid RP-HPLC method has been estab-lished for the analysis of Ribostamycin and impurity Neamine using 1-F1-uoro-2,4-dinitrobenzene (DNFB) pre-column derivatization.

• 本文选用2，4－二硝基氟苯（DNFB）柱前衍生化，二极管阵列紫外检测器检测，建立了核糖霉素及杂质新霉胺的反相快速HPLC测定方法。