In this study, we first hypothesized that DEX potentiates CPA toxicity by inducing CYP3A4 and therefor changing its metabolic fate and pharmacokinetics.

• 在本研究中，先假设DEX通过诱导CYP3A4而改变CYP的两条代谢途径的相对比例，并使其药代动力学发生改变，从而增加CPA的毒性。