In the process of external aldosterone inducing cardiac hypertrophy, the activity of calcineurin increases and the expression of its negative-control factor, the expression of Cain, also increased.

• 在外源性醛固酮诱发大鼠发生心肌肥厚反应过程中,钙调神经磷酸酶的活性增加,而其内源性负性调节蛋白钙调神经磷酸酶抑制因子的表达亦相应增加;