In sharp contrast with TRPC6, single CCh-activated TRPC7 channels were dose-dependently inhibited by increasing [Ca2+]i in the nanomolar range, and no discernible potentiation occurred in the micromolar range of [Ca2+]i.

• 细胞外Ca~(2+)(Ca~(2+)_o，1mmol/L)对TRPC6/TRPC7电流呈现相反调节：对前者是双向效应，先增强后抑制(在有些细胞中，增强效应又可区分为最初的“噪音”样快增强和其后的慢增强，而表现为三向效应)，而对后者则表现出强烈的单向抑制。