In order to search for novel potent antimalarials, a series of ethers and esters of dihydroqinghaosu with halogen, nitrogen and sulfur heteroatoms substisuted in their side chain was prepared.

• 为增强双氢青蒿素酯和醚类衍生物的抗疟作用,我们合成了42个侧链上带有卤素、氮或硫取代的双氢青蒿素酯和醚类化合物。