In order to explore the role of p15 INK4B gene with highly methylated CpG island in the pathogenesis of leukemia, the expression levels of p15 INK4B gene was detected in patients with AML and CML.

• 为探索 p15 INK4B基因在CpG岛高甲基化对白血病发病机制的重要作用 ,应用敏感的甲基化特异的MSP PCR的测定方法 ,测定了 p15 INK4B基因在急性粒细胞白血病 (AML)和慢性粒细胞白血病 (CML)中甲基化的表达变化。