In natural situation, HBV S gene mutations may appear in long time HBV infected patients, and these mutants could alter the conformation of major hydrophilic region(MHR), such as ThrHlAsn, Metl33Thr, Glyl45Ala, et al.

• 自然状态下，长期乙肝病毒感染的患者可出现HBVS基因变异，这些变异(Thr131Asn，Met133Thr，Gly145Ala等)能够改变MHR区决定簇构象；