In humans excessive intake( for adults, over4 milligrams per day) over many years can lead to skeletal fluorosis, a well-defined skeletal disorder, and in some plant species, fluoride is more toxic than ozone, sulfur dioxide, or pesticides.

• 人类过量的摄入（人每天超过4毫克）年以后会导致骨骼氟中毒，一种容易识别的骨骼混乱（症）而且在某些植物中，氟化物的毒性要比臭氧、氧化硫或者杀虫剂都大。